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Related Experiment Videos

Physiological influences on off-finger glucose testing.

G McGarraugh1, D Price, S Schwartz

  • 1TheraSense Inc., Alameda, California 94502, USA. geoff.mcgarraugh@therasense.com

Diabetes Technology & Therapeutics
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

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New blood glucose monitors offer alternative testing sites beyond the finger. While generally accurate, arm readings show a slight lag, potentially delaying hypoglycemia detection. Finger testing remains preferable for rapid glucose change monitoring.

Area of Science:

  • Endocrinology
  • Medical Devices
  • Diabetes Management

Background:

  • Emerging blood glucose monitoring devices allow sample collection from sites other than the fingertip.
  • The FreeStyle Blood Glucose Monitor utilizes minimal blood (0.3 microL) and permits testing on the hand, arm, or leg.

Purpose of the Study:

  • To evaluate the accuracy and reliability of off-finger blood glucose measurements compared to traditional finger testing.
  • To investigate the physiological differences affecting glucose readings from alternate sites.

Main Methods:

  • Two studies were conducted: 1) Comparison of FreeStyle (arm, finger, venous) with YSI 2300 Stat Plus analyzer in 120 diabetes patients. 2) Time-course analysis of glucose variation using simultaneous arm and finger measurements every 15 minutes for 6 hours in 13 type 1 diabetes patients.

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Main Results:

  • FreeStyle measurements from venous and finger samples showed similar regression statistics to the YSI analyzer.
  • Arm sample measurements exhibited greater data scatter compared to finger samples, though regression equations were similar.
  • A 5-20 minute time lag in glucose response was observed on the arm relative to the finger, regardless of glucose trend direction.

Conclusions:

  • Off-finger blood glucose monitoring sites, like the arm, demonstrate a time lag in glucose readings compared to the finger.
  • While not clinically significant by Clarke Error Grid Analysis, this lag may delay the detection of rapidly falling glucose levels, particularly hypoglycemia.
  • For critical monitoring of rapid glucose changes or hypoglycemia, fingertip testing remains the recommended method.