Dual-substrate utilization by Bordetella pertussis
Related Experiment Video
Updated: Oct 3, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
R Neeleman1, M Joerink, C Beuvery
1National Institute of Public Health and the Environment, Laboratory for Product and Process Development, Bilthoven, The Netherlands. Ronald.Neeleman@rivm.nl
Abstract:
To improve the cultivation of Bordetella pertussis and take advantage of the newest techniques in monitoring and control, a quantitative description of substrate utilisation is necessary. Growth of the organism is limited by two main substrates. However neither interactive nor non-interactive modelling seem appropriate. A model that combines essential and enhanced kinetics was developed based on experimental observation. Instead of fitting all model parameters at once, a step-wise experimentation procedure was used. Finally two cultivations showed the accuracy of the model.
More Related Videos
Related Concept Videos
Regulation of Bacterial Virulence
GPCRs Regulate Adenylyl Cylase Activity
Two...

