X-ray diffraction and electron microscopy in the polymorphism study of ondansetron hydrochloride
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Updated: Oct 3, 2026

Microcrystal Electron Diffraction of Small Molecules
Published on: March 15, 2021
J M Llácer1, V Gallardo, R Delgado
1Department of Pharmacy and Pharmaceutical Technology, University of Granada, Spain.
Abstract:
Using different techniques, we studied the possible formation of ondansetron polymorphs. Ondansetron is a carbazol antiemetic that acts as a competitive, selective inhibitor of 5-HT3 serotonin receptors. The polymorphs were determined by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results suggest that the compounds are not true crystallographic polymorphs, but instead are the product of physical structural changes in the drug, which would be of interest pharmaceutically.
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