Related Experiment Videos
X-ray diffraction and electron microscopy in the polymorphism study of ondansetron hydrochloride
J M Llácer1, V Gallardo, R Delgado
1Department of Pharmacy and Pharmaceutical Technology, University of Granada, Spain.
Drug Development and Industrial Pharmacy
|January 5, 2002
Summary
Researchers investigated ondansetron polymorphs using X-ray diffraction and scanning electron microscopy. Findings indicate physical structural changes, not true crystallographic polymorphs, with pharmaceutical relevance.
Area of Science:
- Pharmaceutical Science
- Solid-State Chemistry
Background:
- Ondansetron is a carbazol antiemetic.
- It selectively inhibits 5-HT3 serotonin receptors.
Purpose of the Study:
- To investigate the potential formation of ondansetron polymorphs.
- To characterize any observed structural variations.
Main Methods:
- Employed X-ray diffraction (XRD) for crystallographic analysis.
- Utilized scanning electron microscopy (SEM) for morphological examination.
Main Results:
- Observed structural changes in ondansetron.
- These changes were identified as physical, not true crystallographic polymorphs.
Conclusions:
- Ondansetron does not form true polymorphs under the studied conditions.
- The observed physical structural changes are of pharmaceutical interest.