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Updated: Oct 3, 2026

Paradigms for Pharmacological Characterization of C. elegans Synaptic Transmission Mutants
Published on: August 18, 2008
[Ability of novel non-competitive glutamate receptor blocking agents to weaken motor disorders in animals]
N I Rukoiatkina1, L V Gorbunova, V E Gmiro
1I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., St. Petersburg, 194223, pr. M. Torez, 44, Russia.
Abstract:
Action of mono- and dication derivatives of phenylcyclohexyl was compared with effects of known NMDA-antagonists memantine and dizocilpine. Seizures induced with the NMDA were effectively prevented both by mono- and dications, whereas against the kainate seizures dication alone was effective. Anticataleptic activity was much stronger in monocations, and the side effect of the substances under study on motor co-ordination was obviously weaker than in dizocilpine. Thereupon, the phenylcyclohexyl derivatives might be regarded as potential means for treatment of parkinsonism and other motor disorders.
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