Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunotherapy in allergic rhinitis.

A G Palma-Carlos1, A Spinola-Santos, M B Ferreira

  • 11st Medical Clinic, University Faculty of Medicine, Immuno-Allergology Unit and Hematology, Immunology Center (CHIUL), Lisbon.

Allergie Et Immunologie
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial variability of soil organic carbon in native forest and agroforestry system in central Brazilian Amazonia.

Brazilian journal of biology = Revista brasleira de biologia·2025
Same author

Managing systemic reactions and venom immunotherapy in vespid-venom allergy: observations from a retrospective study of Portuguese patients.

European annals of allergy and clinical immunology·2024
Same author

Efficacy of levamisole, ivermectin and moxidectin against Capillaria spp. in European hedgehogs (Erinaceus europaeus) - CORRIGENDUM.

Journal of helminthology·2024
Same author

Efficacy of levamisole, ivermectin and moxidectin against <i>Capillaria</i> spp. in European hedgehogs (<i>Erinaceus europaeus</i>).

Journal of helminthology·2023
Same author

Optimizing the use of systemic corticosteroids in severe asthma (ROSA II project): a national Delphi consensus study.

Pulmonology·2023
Same author

Unsupervised clustering to differentiate rheumatoid arthritis patients based on proteomic signatures.

Scandinavian journal of rheumatology·2023

Allergen specific immunotherapy (IT) effectively treats allergic rhinitis by reducing symptoms and inflammation. This study confirms IT’s efficacy using various methods, including nasal challenges and antibody response analysis.

Area of Science:

  • Immunology
  • Allergy Research
  • Otorhinolaryngology

Background:

  • Allergen specific immunotherapy (IT) is a primary treatment for allergic rhinitis.
  • Non-invasive routes like oromucosal and nasal administration have gained acceptance, particularly in children.
  • WHO has validated these newer IT administration methods.

Purpose of the Study:

  • To evaluate the efficacy of allergen specific immunotherapy (IT) in treating allergic rhinitis.
  • To assess IT's impact on clinical symptoms, inflammation markers, and specific antibody responses.
  • To validate IT's effectiveness through various assessment methods.

Main Methods:

  • Nasal and oromucosal administration of allergen specific immunotherapy (IT).
  • Assessment of clinical symptom and pharmacological scores.

Related Experiment Videos

  • Measurement of soluble adhesion molecules (sVCAM-1, sICAM-1) in nasal lavage.
  • Evaluation of specific IgE immunoblotting patterns for house dust mites.
  • Analysis of tryptase and eosinophil cationic protein (ECP) in nasal lavage after allergen challenge.

    • Main Results:

    • Nasal and oromucosal IT significantly decreased mean symptom and pharmacological scores in seasonal and perennial allergic rhinitis.
    • A reduction in soluble VCAM-1 (sVCAM-1) levels indicated decreased eosinophilic inflammation.
    • Immunoblotting showed a decrease or disappearance of specific IgE bands for D. pteronyssinus after oromucosal IT.
    • IT led to reduced tryptase and ECP levels in nasal lavage post-allergen challenge.

    Conclusions:

    • Allergen specific immunotherapy (IT) effectively reduces clinical symptoms and markers of allergic inflammation in allergic rhinitis.
    • IT demonstrates efficacy in modulating specific IgE responses and improving tolerance to allergen challenges.
    • The study confirms the overall usefulness and effectiveness of IT in managing allergic rhinitis.