Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Basophils in chronic urticaria.

¹Dermatology Center, West Norwich Hospital, UK.

The Journal of Investigative Dermatology. Symposium Proceedings

|January 5, 2002

Summary

This summary is machine-generated.

Blood basophils are reduced in chronic urticaria, suggesting impaired immune responses. Their migration to skin may drive wheal formation in this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Highlights and recent developments in allergic diseases in EAACI journals (2019).

Clinical and translational allergy·2020

Same author

Correction to: Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018).

Clinical and translational allergy·2020

Same author

Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018).

Clinical and translational allergy·2019

Same author

Definition, aims, and implementation of GA(2) LEN Urticaria Centers of Reference and Excellence.

Allergy·2016

Same author

Improvement in quality of life impairment followed by relapse with 6-monthly periodic administration of omalizumab for severe treatment-refractory chronic urticaria and urticarial vasculitis.

Clinical and experimental dermatology·2014

Same author

Unexplained recurrent fever: when is autoinflammation the explanation?

Allergy·2013

Same journal

Report from the International Dermatology Outcome Measures Initiative.

The journal of investigative dermatology. Symposium proceedings·2020

Same journal

Broadening Diversity in Alopecia Areata Clinical Trial Participants.

The journal of investigative dermatology. Symposium proceedings·2020

Same journal

The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms.

The journal of investigative dermatology. Symposium proceedings·2020

Same journal

A Botanical Compound for the Treatment of Alopecia Areata and Chemotherapy-Induced Alopecia.

The journal of investigative dermatology. Symposium proceedings·2020

Same journal

Burden of Illness in Alopecia Areata: A Cross-Sectional Online Survey Study.

The journal of investigative dermatology. Symposium proceedings·2020

Same journal

Willingness to Pay and QOL in Alopecia Areata.

The journal of investigative dermatology. Symposium proceedings·2020

See all related articles

Area of Science:

Immunology
Dermatology

Background:

Chronic urticaria (CU) is a common skin condition characterized by wheals and itching.
The role of specific immune cells, like basophils, in CU pathogenesis is not fully understood.

Purpose of the Study:

To investigate the levels and function of blood basophils in patients with chronic urticaria.
To explore the potential involvement of basophil recruitment in the development of wheals in CU.

Main Methods:

Quantification of peripheral blood basophil counts.
Assessment of basophil responsiveness to immunologic stimuli.
Analysis of basophil infiltration in skin lesions (implied).

Main Results:

Blood basophil counts were found to be reduced in patients with chronic urticaria.

Related Experiment Videos

Basophils from CU patients exhibited a diminished response to immunologic stimulation.

Conclusions:

Reduced blood basophil levels and impaired function are observed in chronic urticaria.
Active migration of basophils from the blood to lesional skin is a potential key factor in wheal pathogenesis in CU.