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Delayed pressure urticaria.

A Kobza-Black1

  • 1St John's Institute of Dermatology, King's College London, St Thomas Hospital, UK.

The Journal of Investigative Dermatology. Symposium Proceedings
|January 5, 2002
PubMed
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Delayed pressure urticaria causes painful skin swelling hours after pressure application. Current treatments are often ineffective, impacting patient quality of life and necessitating new management strategies.

Area of Science:

  • Dermatology
  • Immunology
  • Allergy

Background:

  • Delayed pressure urticaria (DPU) is a physical urticaria characterized by delayed, painful swelling after sustained skin pressure.
  • DPU significantly impairs patient quality of life, more so than other urticaria types.
  • Its pathogenesis involves mast cell activation and deep dermal inflammation, but remains poorly understood.

Purpose of the Study:

  • To summarize the characteristics of delayed pressure urticaria.
  • To highlight the challenges in its current management.
  • To emphasize the need for improved therapeutic approaches.

Main Methods:

  • Review of existing literature on delayed pressure urticaria.
  • Analysis of clinical presentation and histological findings.

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  • Evaluation of current and potential treatment strategies.

    • Main Results:

    • DPU lesions present as erythematous, painful swellings several hours post-pressure.
    • Histology shows mast cell activation with neutrophil and eosinophil infiltrate, but no vasculitis.
    • Existing treatments, including antihistamines and anti-inflammatories, are often unsatisfactory.

    Conclusions:

    • Delayed pressure urticaria poses significant challenges due to its severity and resistance to conventional therapies.
    • Oral steroids are effective but not suitable for long-term management.
    • Novel management strategies are under investigation for this persistent condition.