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Published on: January 17, 2018
Aneurysmal bone cyst of the nose with 17p13 involvement
V Winnepenninckx1, M Debiec-Rychter, M Jorissen
1University Hospital St-Raphael, Department of Pathology, Katholieke Universiteit Leuven, Belgium.
Abstract:
We report on a 6-year-old girl with a polypoid mass, filling up the entire right nasal cavity as shown on a magnetic resonance imaging scan. Histologically, the tumor had the characteristics of an aneurysmal bone cyst, which is extremely rare in this location. Cytogenetic analysis disclosed a single (6:17)(p21;p13) translocation, confirming a specific genetic involvement in the development of aneurysmal bone cysts. Fluorescent in situ hybridization analysis mapped the putative gene between the p53 (17p13.1) and the Mieller-Dieker gene (17p13.3) loci.
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