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Related Experiment Videos

Cellular screening assays using fluorescence microscopy.

R A Blake1

  • 1Sugen Inc., South San Francisco, CA 94080-4811, USA. robert-blake@sugen.com

Current Opinion in Pharmacology
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

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Automated fluorescence imaging systems now enable compound screening using fluorescence microscopy. New fluorescent tools will expand applications in multichannel imaging assays for drug discovery.

Area of Science:

  • Biotechnology
  • Cell Biology
  • Pharmacology

Background:

  • Automated fluorescence imaging systems have advanced fluorescence microscopy.
  • This technique provides rich data for biological and chemical screening.

Purpose of the Study:

  • To highlight the utility of automated fluorescence imaging in compound screening.
  • To discuss the impact of novel fluorescent probes on imaging assays.

Main Methods:

  • Utilizing automated fluorescence imaging systems for microscopy-based screening.
  • Applying multichannel fluorescence imaging assays.

Main Results:

  • Fluorescence microscopy is now effective for compound screening.
  • Applications include screening kinase inhibitors, receptor internalization, and protein modification.

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Conclusions:

  • Automated fluorescence imaging is a powerful tool for compound screening.
  • Novel fluorescent proteins and dyes will enhance multichannel imaging capabilities.