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Updated: Oct 3, 2026

Biochemical Measurement of Neonatal Hypoxia
Published on: August 24, 2011
2-Alkyloxyalkylthiohypoxanthines as new potent inhibitors of xanthine oxidase
G Biagi1, I Giorgi, F Pacchini
1Dipartimento di Scienze Farmaceutiche, Università di Pisa, Italy.
Abstract:
The title compounds were prepared and tested as xanthine oxidase (XO) inhibitors. Results evidenced that potency was related to the position of the oxygen atom in the 2-linear chain and that it grew with distance from the sulfur atom until it became equipotent to 2-n-hexylthiohypoxanthine. Enzymatic oxidation on C(2) occurred in the 8-alkylthiohypoxanthines. On the contrary, oxidation on C(8) did not occur in the 2-alkythioderivatives, demonstrating that the chain forced these molecules to form a complex with molybdenum(VI) involving only the N(3) and N(9) nitrogen atoms.
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