Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pharmacologic interventions in suicide prevention.

L Tondo1, C Ghiani, M Albert

  • 1Department of Psychology, University of Cagliari, Sardinia, Italy.

The Journal of Clinical Psychiatry
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lithium response in families can inform the selection of long-term treatment of bipolar disorder.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology·2026
Same author

Family History and Solar Insolation in Bipolar I Disorder.

Acta psychiatrica Scandinavica·2026
Same author

Interaction Induced Anderson Transition in a Kicked One Dimensional Bose Gas.

Physical review letters·2025
Same author

[Thoracoabdominal impalement injury with aortic involvement : Case report and review of the literature].

Unfallchirurgie (Heidelberg, Germany)·2025
Same author

Defining Standard Data Reporting in Pelvic Exenterations for Non-Rectal Cancers: A Systematic Review of Current Data Reporting.

Cancers·2025
Same author

Symmetry Oscillations in Strongly Interacting One-Dimensional Mixtures.

Physical review letters·2024
Same journal

Major Depressive Disorder and PTSD Treatment Outcome in Interpersonal Psychotherapy and Prolonged Exposure.

The Journal of clinical psychiatry·2026
Same journal

Psychiatrists and Medical Aid in Dying: Entering Uncharted Waters.

The Journal of clinical psychiatry·2026
Same journal

Mind and Metabolism in Crisis: US Mortality Involving Obesity and Psychiatric Disorders-Trends, Disparities, and ARIMA Projections.

The Journal of clinical psychiatry·2026
Same journal

Generative AI for the Clinical Psychopharmacologist: Is It Ready for Prime Time?

The Journal of clinical psychiatry·2026
Same journal

Posttrauma Benzodiazepine Use and Subsequent PTSD: A Population-Wide Analysis Following Extreme Traumatic Exposure.

The Journal of clinical psychiatry·2026
Same journal

The Challenges of PTSD Prevention: Placing Benzodiazepine Use in Context.

The Journal of clinical psychiatry·2026
See all related articles

Suicide rates remain high globally, with individuals experiencing mental disorders facing increased risk. Lithium is the only medication consistently proven to reduce suicide risk in patients with mental illness, particularly bipolar disorder.

Area of Science:

  • Psychiatry and Mental Health
  • Neuroscience
  • Public Health

Background:

  • Global suicide rates are not declining, highlighting an ongoing public health crisis.
  • Individuals with mental disorders have a significantly higher risk of suicide compared to the general population.
  • Existing pharmacologic interventions for suicide risk reduction show inconsistent efficacy.

Purpose of the Study:

  • To review the evidence for pharmacologic interventions aimed at reducing suicide risk.
  • To identify medications with consistent antisuicidal effects, particularly in vulnerable populations.
  • To emphasize the unique role of lithium in suicide prevention.

Main Methods:

  • Systematic review of existing literature on pharmacologic treatments for suicide risk.

Related Experiment Videos

  • Analysis of clinical trial data and meta-analyses focusing on various mental disorders.
  • Evaluation of evidence strength for reported antisuicidal effects of different medications.

    • Main Results:

    • Pharmacologic interventions for suicide prevention yield inconsistent results across studies.
    • Lithium is the sole medication with robust and consistent evidence demonstrating an antisuicidal effect.
    • The antisuicidal efficacy of lithium is particularly noted in patients with bipolar disorder.

    Conclusions:

    • There is a critical need for effective suicide prevention strategies in mental health care.
    • Lithium monotherapy represents a consistently effective pharmacologic option for reducing suicide risk.
    • Further research should explore mechanisms underlying lithium's antisuicidal properties and optimize its use.