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[Anal carcinoma].

N Belnome1, M Salibra, V Bartolo

  • 1Cattedra di Chirurgia Generale, Università degli Studi di Messina.

Annali Italiani Di Chirurgia
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

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Abdominal perianal rectum amputation is being replaced by combined radio-chemotherapy for anal neoplasia. This approach shows improved remission and survival rates, particularly for early-stage cancers.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Context:

  • Abdominal perianal rectum amputation was a historical standard for anal neoplasia.
  • Evolving treatment paradigms now favor less invasive, multimodal approaches.
  • Patient outcomes have historically varied with different treatment strategies.

Purpose:

  • To evaluate the efficacy of combined radio-chemotherapy versus traditional surgery for anal neoplasia.
  • To assess the historical shift in treatment protocols for anal cancer.
  • To analyze long-term survival data for patients with anal cancer.

Summary:

  • A retrospective analysis of 54 patients treated between 1963 and the present was conducted.
  • Early studies using the Greenall protocol showed partial remission in 50-62.5% of cases.

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  • More recent cohorts treated with combined radio-chemotherapy, especially for Stages I and II squamous cell carcinoma, achieved 100% remission.
  • Five-year survival rates for combined therapy were approximately 70% higher than for surgery alone.

    • Impact:

    • Combined radio-chemotherapy offers superior remission and survival rates for anal neoplasia compared to surgery alone.
    • This study highlights the successful transition to modern, less invasive oncological treatments.
    • Findings support the adoption of neoadjuvant or definitive radio-chemotherapy for specific anal cancer presentations.