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[Vasoconstrictor responsiveness of rat basilar artery enhanced by simulated weightlessness]
1Department of Aerospace Physiology, The Fourth Military Medical University, Xi'an, China.
Objective:
To investigate the effects of simulated weightlessness on contractile responsiveness of the basilar artery.
Methods:
Rats were subjected to tail-suspension for 4-wk to simulate the effect of weightlessness, responses of perfused isolated basilar arterial rings to various vasoactive compounds were examined.
Results:
Maximal isometric contractile responses to KCl [ (10~100) mmol/L], arginine vasopressin [AVP, (10(-15)~10(-7) mol/L], or 5-hydroxytryptamine [5-HT, (10(-12) ~ 10(-4) mol/ L] were significantly enhanced in arterial rings isolated from 4-wk tail-suspended as compared with that from simultaneous control rats.
Conclusion:
These results indicate that medium-term simulated weightlessness may result in an enhanced contractile responsiveness in rat basilar artery, and strongly support the hypothesis of cerebrovascular syncope-initiating mechanism.
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