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Updated: Oct 3, 2026

Protein Target Prediction and Validation of Small Molecule Compound
Published on: February 23, 2024
Medical target prediction from genome sequence: combining different sequence analysis algorithms with expert
T Dandekar1, F Du, R H Schirmer
1European Molecular Biology Laboratory, PO Box 102209, Meyerhostrasse 1, D-69012 Heidelberg, Germany. dandekar@embl-heidelberg.de
Abstract:
By exploiting the rapid increase in available sequence data, the definition of medically relevant protein targets has been improved by a combination of: (i) differential genome analysis (target list): and (ii) analysis of individual proteins (target analysis). Fast sequence comparisons, data mining, and genetic algorithms further promote these procedures. Mycobacterium tuberculosis proteins were chosen as applied examples.
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