Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transient dynamics and early diagnostics in infectious disease.

M Mohtashemi1, R Levins

  • 1Department of Computer Science, Massachusetts Institute of Technology, 545 Technology Square, Room 421, Cambridge, MA 02139, USA. mojdeh@medg.lcs.mit.edu

Journal of Mathematical Biology
|January 5, 2002
PubMed
Summary

This study introduces transient pathology, focusing on short-term immune system and pathogen interactions. It highlights how early infection dynamics, not long-term behavior, determine acute disease severity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toward an integrated epidemiology.

Trends in ecology & evolution·2011
Same author

Is capitalism a disease? The crisis in U.S. public health.

Monthly review (New York, N.Y. : 1949)·2007
Same author

Anthropometric variability in the USA: 1971-2002.

Annals of human biology·2005
Same author

The role of seasonality in the dynamics of deer tick populations.

Bulletin of mathematical biology·2005
Same author

The precautionary principle in environmental science.

Environmental health perspectives·2001
Same author

Let the numbers speak.

International journal of health services : planning, administration, evaluation·2000

Area of Science:

  • Mathematical modeling
  • Infectious disease dynamics
  • Immunology

Background:

  • Traditional infectious disease models prioritize long-term pathogen behavior and steady states.
  • For acute infections, host and population health are primarily impacted by short-term dynamics.
  • The long-term behavior of pathogens is often less relevant for acute disease outcomes.

Purpose of the Study:

  • To introduce and define the concept of transient pathology in infectious diseases.
  • To shift focus from long-term dynamics to the critical short-term interactions between the immune system and pathogens.
  • To understand the early stages of infection and their impact on acute disease severity.

Main Methods:

  • Developing mathematical models that emphasize short-term dynamics.

Related Experiment Videos

  • Analyzing the amplifying effect of an immature immune system on initial pathogen growth.
  • Formalizing the underlying dynamics of early infection pathogenesis.

    • Main Results:

    • Identified the significant impact of early pathogen dynamics on acute infection severity.
    • Quantified the amplifying effect of immune system absence on initial pathogen load.
    • Derived key measures of transient pathogenicity: peak infection and time to peak.

    Conclusions:

    • Transient pathology, focusing on early infection dynamics, is crucial for understanding acute disease.
    • Peak infection and time to peak are vital metrics for assessing infection severity and guiding early interventions.
    • Mathematical models should incorporate transient dynamics to better predict and manage acute infectious diseases.