[Prevention of postoperative scar processes in otorhinolaryngology experimental rationale]

It is shown in vitro that fibroblast proliferation may be inhibited by 5-fluorouracil (5-Fu). In stimulated growth of the fibroblasts the 5-Fu antiproliferative effect takes place even in minimal concentration (2 mcg/ml). Fibroblastic proliferative activity recovers after elimination of 5-Fu from the medium at concentration under 63 mcg/ml.