Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nuclear envelope and nuclear matrix: interactions and dynamics.

S Vlcek1, T Dechat, R Foisner

  • 1Department of Biochemistry and Molecular Cell Biology, Vienna Biocenter, University of Vienna, Austria.

Cellular and Molecular Life Sciences : CMLS
|January 5, 2002
PubMed
Summary

The nuclear lamina, crucial for cell structure, connects the nuclear envelope to the internal nuclear matrix via specific proteins. Understanding these connections is vital for studying diseases linked to nuclear lamina defects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of lamin A function increases chromatin dynamics in the nuclear interior.

Nature communications·2015
Same author

Lamina-independent lamins in the nuclear interior serve important functions.

Cold Spring Harbor symposia on quantitative biology·2011
Same author

The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity.

Oncogene·2007
Same author

Mitochondrial genotype and risk for Alzheimer's disease: cross-sectional data from the Vienna-Transdanube-Aging "VITA" study.

Journal of neural transmission (Vienna, Austria : 1996)·2004
Same author

Intermediate filaments: novel assembly models and exciting new functions for nuclear lamins.

Cellular and molecular life sciences : CMLS·2003
Same author

Inner nuclear membrane proteins and the nuclear lamina.

Journal of cell science·2001

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Structural Biology

Background:

  • The peripheral nuclear lamina is a protein network lining the inner nuclear membrane.
  • It comprises lamin filaments and integral membrane proteins like LAP1, LAP2, and lamin B receptor.
  • Nuclear membrane proteins interact with chromatin proteins such as BAF and Hp1.

Purpose of the Study:

  • To elucidate the structural connections between the peripheral nuclear lamina and the internal nuclear matrix.
  • To investigate the roles of LAP2 family members, Tpr, and Nup153 in mediating these structural links.
  • To discuss the implications of these findings for human diseases caused by nuclear lamina protein mutations.

Main Methods:

  • The study describes the structural links based on existing knowledge and potentially new experimental data (details not provided in abstract).

Related Experiment Videos

  • Focus on the interactions between peripheral and internal nuclear components.
  • Relating structural findings to disease pathology.

    • Main Results:

    • Structural links between the peripheral lamina and internal nuclear matrix are identified.
    • LAP2 family members, Tpr, and Nup153 are implicated as key mediators of these connections.
    • These structural insights provide a basis for understanding diseases linked to nuclear lamina protein mutations.

    Conclusions:

    • LAP2 proteins, Tpr, and Nup153 are crucial for connecting the nuclear lamina to the internal nuclear matrix.
    • Disruptions in these structural connections may underlie various human diseases.
    • Further research into these interactions can inform therapeutic strategies for lamina-related disorders.