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Cold activation of complement and kinin.

M Kondo, S Takemura, T Yoshikawa

    Advances in Experimental Medicine and Biology
    |January 1, 1979
    PubMed
    Summary
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    Cold activation of complement differs from coagulation and kinin systems. Tranexamic acid

    Area of Science:

    • Immunology
    • Hematology

    Background:

    • Cold activation of complement exhibits similarities to cold-promoted activation of factor VII.
    • Kallikrein and Hageman factor are implicated in factor VII activation.

    Purpose of the Study:

    • To investigate the relationship between cold activation of complement and factor VII activation.
    • To determine if coagulation or kinin systems are involved in cold complement activation.

    Main Methods:

    • Investigating differences between serum and plasma complement.
    • Assessing the effect of tranexamic acid on cold complement activation.

    Main Results:

    • Cold activation of complement is distinct from coagulation and kinin systems.
    • Tranexamic acid, an antiplasmin, inhibited cold complement activation.

    Related Experiment Videos

  • Plasmin may play a role in cold complement activation in specific circumstances.
  • Conclusions:

    • Cold activation of complement is not directly linked to the coagulation or kinin systems.
    • The involvement of plasmin suggests a complex mechanism for cold complement activation.