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Updated: Aug 2, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

Cancer research 2001: drug resistance, new targets and drug combinations

H J Broxterman1, N Georgopapadakou

  • 1Department of Medical Oncology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands. H.Broxterman@vumc.nl

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy
|January 5, 2002
PubMed

Insights

Researchers are exploring new anticancer drugs and targets, focusing on resistance mechanisms and novel molecular technologies. Advances in gene screening enable better identification of drug targets and resistance pathways.

Area of Science:

  • Oncology
  • Pharmacology
  • Biotechnology

Background:

  • The development of novel anticancer therapeutics and drug targets is a critical area of research for academic institutions and the pharmaceutical industry.
  • The 92nd Annual Meeting of the American Association for Cancer Research (AACR) showcased recent advancements in cancer research.

Framework:

  • This summary highlights key themes from the AACR meeting, including drug resistance mechanisms, emerging drug targets, and innovative molecular technologies.
  • Focus areas include efflux and target modulation for resistance, and topoisomerase, angiogenesis, and cell cycle inhibitors as new therapeutic strategies.

Implementation:

  • High-throughput screening technologies, such as those for concurrent gene expression analysis, are revolutionizing the identification of molecular targets.
  • These technologies facilitate the understanding of drug mechanisms of action and resistance.

Implications:

  • Simultaneous inhibition of multiple targets is emerging as a crucial strategy in cancer treatment, as discussed in several presentations.
  • These advancements promise to accelerate the discovery and development of more effective cancer drugs.

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