Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional imaging studies on dopamine and motor control.

D J Brooks1

  • 1MRC Clinical Sciences Centre, Hammersmith Hospital, London, United Kingdom.

Journal of Neural Transmission (Vienna, Austria : 1996)
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impulse control disorders are associated with lower ventral striatum dopamine D3 receptor availability in Parkinson's disease: A [<sup>11</sup>C]-PHNO PET study.

Parkinsonism & related disorders·2021
Same author

Exercise protects synaptic density in a rat model of Parkinson's disease.

Experimental neurology·2021
Same author

Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder.

European journal of neurology·2019
Same author

Abaloparatide increases bone mineral density and bone strength in ovariectomized rabbits with glucocorticoid-induced osteopenia.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2019
Same author

Prevalence and duration of non-motor symptoms in prodromal Parkinson's disease.

European journal of neurology·2019
Same author

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy.

Movement disorders : official journal of the Movement Disorder Society·2017

Dopamine plays a key role in motor control. Tonic dopamine in the basal ganglia optimizes familiar actions, while phasic dopamine release aids motor learning and rewarded tasks.

Area of Science:

  • Neuroscience
  • Motor Control Research
  • Dopamine Function

Background:

  • Dopamine is crucial for motor control.
  • Previous studies used PET and MR imaging to investigate dopamine's role.

Purpose of the Study:

  • To review insights from PET and MR activation studies on dopamine's role in motor control.
  • To compare regional cerebral blood flow (rCBF) changes during various motor tasks in normal subjects and Parkinson's disease patients.
  • To contrast dopamine release during rewarded and unrewarded actions using 11C-raclopride.

Main Methods:

  • Review of Positron Emission Tomography (PET) and Magnetic Resonance (MR) activation studies.
  • Comparison of regional cerebral blood flow (rCBF) changes during motor tasks.
  • Assessment of striatal binding of 11C-raclopride to measure dopamine release.

Related Experiment Videos

Main Results:

  • Tonic dopamine release in the basal ganglia optimizes motor programs during unrewarded, familiar actions.
  • Phasic dopamine release occurs during motor learning and rewarded tasks.
  • Dopamine release patterns differ between normal subjects and Parkinson's disease patients.

Conclusions:

  • Dopamine's tonic and phasic release differentially regulate motor control and learning.
  • Basal ganglia dopamine optimizes execution of familiar motor programs.
  • Additional dopamine release enhances attention and reinforces learning in novel or rewarded situations.