Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Time, place and positional value in the chick limb-bud.

D Summerbell, J H Lewis

    Journal of Embryology and Experimental Morphology
    |June 1, 1975
    PubMed
    Summary

    The progress zone theory of limb development is mathematically formulated and quantitatively supported. Experiments show limb parts develop sequentially from a growth zone, not via long-range signals.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    McSART: an iterative model-based, motion-compensated SART algorithm for CBCT reconstruction.

    Physics in medicine and biology·2019
    Same author

    A prospective gating method to acquire a diverse set of free-breathing CT images for model-based 4DCT.

    Physics in medicine and biology·2018
    Same author

    SU-E-J-210: Lung Tumor Target Volume Contours on EPID Cine Mode Images.

    Medical physics·2017
    Same author

    3D fluoroscopic image estimation using patient-specific 4DCBCT-based motion models.

    Physics in medicine and biology·2015
    Same author

    Letter: antibiotic dose adjustment in patients with advanced liver disease--authors' reply.

    Alimentary pharmacology & therapeutics·2013
    Same author

    Review article: prescribing medications in patients with cirrhosis - a practical guide.

    Alimentary pharmacology & therapeutics·2013

    Area of Science:

    • Developmental biology
    • Regenerative medicine
    • Morphogenesis

    Background:

    • The progress zone theory explains limb development.
    • Limb development involves sequential specification of parts.

    Purpose of the Study:

    • To provide quantitative experimental evidence for the progress zone theory.
    • To mathematically formulate the progress zone theory of limb development.

    Main Methods:

    • Mathematical modeling of the progress zone theory.
    • Experimental manipulation of chick wing-buds (exchange of distal tips).
    • Autoradiographic analysis of cell division.

    Main Results:

    • Limb parts are specified in proximo-distal succession by an autonomous timing mechanism.
    • No long-range morphogenetic signals exist from proximal to distal limb tissue.
    • The width of the progress zone was calculated, with most cells actively dividing.

    Conclusions:

    • The progress zone theory is quantitatively supported by experimental evidence.
    • Limb development is regulated by a localized growth zone and intrinsic timing.
    • Cellular proliferation within the progress zone is crucial for limb patterning.

    Related Experiment Videos