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Related Experiment Videos

Cytochrome P450 database.

A V Lisitsa1, S A Gusev, I I Karuzina

  • 1Institute of Biomedical Chemistry, Pogodinskaya, 10, 119832 Moscow, Russia. fox@ibmh.msk.su

SAR and QSAR in Environmental Research
|January 5, 2002
PubMed
Summary
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This study introduces a specialized database for cytochrome P450 (CYP450) enzymes, offering comprehensive information on their nomenclature, function, and interactions. The database enhances research accessibility through flexible browsing and searching capabilities.

Area of Science:

  • Biochemistry
  • Enzymology
  • Bioinformatics

Background:

  • The cytochrome P450 (CYP450) superfamily is crucial for metabolizing diverse compounds.
  • Comprehensive and accessible data on CYP450 enzymes is essential for research and drug development.
  • Existing resources may lack integrated information on nomenclature, function, and interactions.

Purpose of the Study:

  • To describe a specialized database for the cytochrome P450 superfamily.
  • To provide a centralized resource for CYP450 nomenclature, structure, function, and related data.
  • To develop a flexible interface for accessing and analyzing CYP450 information.

Main Methods:

  • Development of a dedicated database management system for CYP450 data.
  • Integration of information on enzyme nomenclature, structure, function, catalyzed reactions, substrate preferences, induction, and inhibition.

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  • Inclusion of source genes, translated proteins, and literature references.
  • Implementation of a flexible programming solution for data browsing, searching, grouping, and reporting.

    • Main Results:

    • A specialized database for the cytochrome P450 superfamily is established.
    • The database provides comprehensive information including nomenclature, function, reactions, and genetic origins.
    • Flexible browsing, searching, and reporting functionalities are available.
    • Both local (CD-ROM) and network (Internet) versions are distributed, with the network version supporting online data extension.

    Conclusions:

    • The developed database offers a valuable, integrated resource for CYP450 research.
    • The flexible interface enhances data accessibility and analysis for scientists.
    • The network version's online extension capability ensures the database remains current and comprehensive.