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Related Concept Videos

Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

Overview
Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
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Receptor-Mediated Endocytosis01:20

Receptor-Mediated Endocytosis

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Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
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Pathogen colonization of host tissues is a critical step in the development of infectious diseases. Various pathogenic microorganisms, including bacteria, fungi, viruses, and protozoa, have evolved complex strategies to attach to, invade, and persist within host environments. These mechanisms enable pathogens to establish infections, evade immune responses, and resist antimicrobial treatments.Attachment to Host CellsIn bacteria, colonization typically begins with adherence to host epithelial...

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Updated: Jun 28, 2026

A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
13:56

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Published on: July 18, 2013

Receptor-ligand interactions and cellular signalling at the host-parasite interface.

T P Yoshino1, J P Boyle, J E Humphries

  • 1Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison 53706, USA. yoshinot@svm.vetmed.wisc.edu

Parasitology
|January 5, 2002
PubMed
Summary

Understanding trematode-snail interactions requires identifying molecules mediating communication. This review explores receptor-ligand signaling at the host-parasite interface, crucial for parasite development and host immune responses.

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Area of Science:

  • Parasitology
  • Molecular Biology
  • Immunology

Background:

  • Host-parasite interactions are complex, with limited understanding of molecular mechanisms.
  • Receptor-mediated events are presumed to mediate snail-trematode communication.
  • Key interactions involve immune responses, larval migration, and nutrient acquisition.

Purpose of the Study:

  • To review molecular mediators of communication between larval trematodes and snail hosts.
  • To focus on receptor-ligand interactions at the host-parasite interface.
  • To discuss molecular exchange regulating parasite development and host responses.

Main Methods:

  • Literature review of molecular mechanisms in snail-trematode interactions.
  • Focus on receptor-ligand and cell-cell adhesion molecules.
  • Analysis of signaling pathways and molecular binding.

Main Results:

  • Molecular exchange at the host-parasite interface is complex and dynamic.
  • Specific molecular interactions appear to be regulated.
  • Snail cell receptors interact with sporocyst tegument and secretions.
  • Host adhesion receptors and sporocyst tegumental receptors are involved.

Conclusions:

  • Identifying specific molecules is crucial for understanding trematode-snail interactions.
  • Receptor-ligand signaling plays a vital role in mediating these interactions.
  • Further research is needed to elucidate the precise molecular mechanisms involved.