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Summary
Zygomycosis, a rare fungal infection, can be fatal. Early diagnosis and aggressive treatment, including surgery and liposomal amphotericin B, are crucial for managing this invasive rhino-ocular disease.
Area of Science:
- Mycology
- Infectious Diseases
- Ophthalmology
Background:
- Zygomycosis is a rare, highly invasive fungal infection with a high mortality rate.
- This case highlights the rhino-ocular form, a severe manifestation.
Observation:
- A 67-year-old diabetic male presented with symptoms including headache, facial swelling, proptosis, and black nasal discharge.
- Fungal elements invaded facial tissues, paranasal sinuses, and orbit, with tooth extraction as a potential entry point.
Findings:
- Microscopic examination of debridement tissue confirmed the causative agent.
- The patient underwent extensive surgery (maxillectomy, ethmoidectomy, sphenoidectomy, orbital exenteration) and treatment with liposomal amphotericin B.
Implications:
- Early diagnosis and aggressive surgical debridement are vital for improving outcomes in zygomycosis.
- Liposomal amphotericin B demonstrated effective fungal infection control with minimal adverse effects, suggesting its utility in treatment.