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[Relation between certain parameters of renal function and prognosis in multiple myeloma]
Medicinski Arhiv
|January 5, 2002
Summary
Renal failure is common in multiple myeloma (MM), with high creatinine, calcium, and Bence-Jones protein in urine indicating poor prognosis. Early identification of these markers is crucial for managing MM patients.
Area of Science:
- Nephrology
- Hematology
- Oncology
Context:
- Renal involvement is a frequent complication of multiple myeloma (MM).
- Pathogenesis involves monoclonal light chain overproduction and hypercalcemia.
- Approximately 25% of MM patients experience renal failure, with over half showing some renal pathology.
Purpose:
- To investigate the clinical presentation and prognostic significance of renal impairment in multiple myeloma (MM) patients.
- To identify key indicators of renal dysfunction and their correlation with patient outcomes.
Summary:
- A retrospective study of 16 MM patients (1996-1999) revealed common signs of renal dysfunction including elevated creatinine, hematuria, pyuria, and proteinuria.
- Renal failure occurred in 10/16 patients. High plasma creatinine, calcium, and Bence-Jones protein in urine were associated with severe renal failure and poor prognosis.
- Mortality during hemodialysis was 19% (3/16), and Bence-Jones protein was detected in 43% (7/16) of patients.
Impact:
- Elevated creatinine, calcium, and urinary Bence-Jones protein are identified as adverse prognostic markers in MM.
- Highlights the critical need for monitoring renal function in MM patients.
- Informs clinical management strategies for MM patients with renal complications.