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[Efficiency of high-flow dialyzers in removal of beta-2-microglobulin]
Background:
[corrected] Beta-2-microglobulin (beta 2M) is protein with a molecular weight of 11.800 Daltons. A 30-fold or greater increase is found in patients(pts) over 10 years (ys) on haemodialysis (HD). The main aim of study is to evaluate high-flux (HF) dialyzer efficacy on beta 2M removal.
Methods:
A sample of 15 pts was selected, 9 males and 6 females, aged 45.7 ys (31.60), mean duration on HD 156,3 months. All pts were dialyzed by standard bicarbonate HD. We used 2 type of HF membrane: cellulose diacetate (CDA) and polysulphone (PS). A blood sample for beta 2M was drown before HD, 20 minute after start of HD (for clearance beta 2M) and after HD.
Results:
Average plasma beta 2M concentration was 53.15 mg/L (27-fold increase than normal values). Post/pre beta 2M ratio was 0.73 with clearance of 23.1 +/- 8.9 ml/min (QB = 250 ml/min, QD = 600 ml/min) for CDA dialyzers, and post/pre beta 2M ratio 0.51 with clearance of 31.9 +/- 4.5 ml/min(QB = 250 ml/min, QD = 600 ml/min) for PS dialyzer, respectively. The CDA membrane was able to remove 103 +/- 29 mg of beta 2M during a 4-hours HD session, and PS membrane 139 +/- 5,1 mg, respectively.
Conclusion:
The only HF membranes are efficient on beta 2M removal.