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[Effect of lower androgen levels on arteriosclerosis]
1Department of Urologic Surgery, People's Hospital, Peking University, Beijing 100044, China.
Objective:
To analyse the effect of lower androgen levels on risk factors for arteriosclerosis of men.
Methods:
In 30 cases of primary prostate carcinoma (stage A), serum levels of testosterone (T), free testosterone (FT), dehydroepiandrosterone (DHEA), sex hormone-binding globulin (SHBG), prostatic specific antigen(PSA), triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), apoprotein alpha 1 (APO alpha 1) and apoprotein beta(APO beta), insulin, plasma fibrinopeptide A (FPA), plasminogen activator inhibitor-1(PAI-1), fibrinogen were determined before and 1 week, 1,4,8 months after castration.
Results:
T, FT, PSA decreased significantly 1 week after castration, and kept on decreasing afterwards. DHEA and SHBG were not changed. TG, fasting insulin and glucose, 2-hour insulin and glucose elevated significantly 1 month after castration. TG, LDL-C, FPA and PAI-1 elevated 4 months after castration. Insulin sensitive index(ISI) decreased significantly 1 month after operation (-4.4 +/- 0.4 vs. -3.5 +/- 0.4, P < 0.01). HDL-C, APO alpha 1, APO beta and fibrinogen were not changed. There was a negative linear correlation between FT and TG, TC, LDL-C, PAI-1, FPA, fasting insulin and glucose, 2 h insulin and glucose, so did T.
Conclusion:
Lower androgen levels have adverse effect on lipid metabolism, coagulative function and insulin sensitivity, which are related to arteriosclerosis of men.