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[Expression of COX-2 in prostatic cancer and benign prostatic hyperplasia]
1Department of Urologic Surgery, Beijing Military General Hospital, Beijing 100700, China.
Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|January 5, 2002
Abstract
Objective:
To investigate the expression of COX-2 in and benign prostatic hyperplasia and prostate cancer and its clinical implications.
Methods:
Forty-two patients with and benign prostatic hyperplasia and 16 with prostate cancer were studied by immunohischemistry and western blot.
Results:
Immunohischemiscal study showed positive results in 15 of the 16 patients and 11 of the 42 patients. Western blot showed that the expression of COX-2 was higher in prostate cancer than in and benign prostatic hyperplasia tissues(P < 0.01).
Conclusion:
Overexpression of COX-2 in prostate cancer may be related to the staging of prostate cancer.