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Related Experiment Videos

Elective radiation therapy for high-risk malignant melanomas.

J S Cooper1, W S Chang, R Oratz

  • 1Department of Radiation Oncology, New York University School of Medicine, New York, USA.

Cancer Journal (Sudbury, Mass.)
|January 5, 2002
PubMed
Summary

Elective radiation therapy after surgery significantly improved local-regional control rates for high-risk melanoma patients. While effective for residual disease, improved systemic therapies are needed to enhance overall survival.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • High-risk malignant melanomas often present with local-regional recurrence rates of 30%-50% post-surgery.
  • Risk factors include multiple lymph node involvement, extracapsular spread, deep invasion, recurrent disease, and involved margins.

Purpose of the Study:

  • To evaluate the efficacy of elective radiation therapy in managing high-risk malignant melanoma after surgical resection.
  • To report initial outcomes of adjuvant radiation in a selected patient cohort.

Main Methods:

  • A cohort of 40 patients with high-risk melanoma received elective radiation therapy post-surgery between 1993 and 1999.
  • Radiation doses varied: 3000 cGy in five fractions (twice weekly) or 3600 cGy in six fractions.

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Main Results:

  • The actuarial 5-year local-regional control rate was 84% at a median follow-up of 18.4 months.
  • Systemic recurrence rates were comparable to historical data for this patient subset.
  • The actuarial overall survival rate at 5 years was 39%.

Conclusions:

  • Elective radiation therapy effectively controls subclinical disease post-melanoma surgery.
  • Adjuvant systemic therapies require development to reduce distant metastases and improve survival outcomes.