Related Experiment Video
Updated: Aug 8, 2026

06:49
Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice
Published on: February 12, 2018
Executive summary: Stages of Reproductive Aging Workshop (STRAW)
M R Soules1, S Sherman, E Parrott
1Division of Reproductive Endocrinology and Infertility, University of Washington, USA.
Climacteric : the Journal of the International Menopause Society
|January 5, 2002
Summary
The Stages of Reproductive Aging Workshop (STRAW) created a standardized staging system for women's reproductive years. This addressed the need for clear terminology in reproductive aging research.
Area of Science:
- Reproductive Endocrinology
- Women's Health Research
- Biomedical Gerontology
Background:
- The reproductive years in women lack a standardized staging system.
- Confusing nomenclature hinders clear communication in reproductive aging studies.
- A need exists for a unified system to describe reproductive transitions.
Framework:
- The Stages of Reproductive Aging Workshop (STRAW) was convened to address these issues.
- STRAW aimed to develop a consensus-based staging system for reproductive aging.
- The workshop focused on defining distinct stages of reproductive life.
Implementation:
- Investigators convened in Park City, Utah, in July 2001.
- The workshop involved structured discussions and expert consensus-building.
- Key outcomes included the proposed STRAW staging system and revised terminology.
Implications:
- The STRAW system provides a framework for clinical research and practice.
- Standardized staging facilitates comparisons across studies on women's reproductive health.
- Improved nomenclature enhances clarity in scientific literature and patient communication.
Related Concept Videos
Oogenesis
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Life Histories
Constrained by limited energy and resources, organisms must compromise between offspring quantity and parental investment. This trade-off is represented by two primary reproductive strategies; K-strategists produce few offspring but provide substantial parental support, whereas r-strategists produce much progeny that receives little care. These strategies are related to an organism’s survival likelihood across its lifespan, which is represented by a survivorship curve. Three general types of...
Replicative Cell Senescence
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Menopause
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Aging
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

