Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Sepsis--continual pathogenetic, diagnostic and therapeutic problem].

P Zdziarski1, K Simon

  • 1Wojskowa Stacja Sanitamo-Epidemiologiczna we Wrocławiu. pzdziarski@witi.wroc.pl

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|January 5, 2002
PubMed
Summary

Sepsis, a severe infection response, causes organ dysfunction and high mortality. Understanding its pathogenesis, diagnosis, and therapy, including antibiotic selection, is crucial for effective treatment and improved patient outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Demographic and Health Sorting Among Nursing Home Residents.

Journal of aging & social policy·2026
Same author

Halogenated persistent organic pollutants in selected processed small fish species from Ghana.

Food chemistry·2025
Same author

Collective aeromedical evacuations of SARS-CoV-2-related ARDS patients in a military tactical plane: a retrospective descriptive study.

BMJ military health·2021
Same author

Serum betatrophin and irisin levels in hepatocellular carcinoma.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2020
Same author

Medical evacuations of members of the French armed forces for infectious diseases in foreign operations.

Medecine et maladies infectieuses·2019
Same author

Serum endocan level in diabetes mellitus of patients with cirrhosis and risk of subsequent development of spontaneous bacterial peritonitis.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2019

Area of Science:

  • Infectious Diseases
  • Immunology
  • Critical Care Medicine

Context:

  • Sepsis is a life-threatening condition characterized by systemic inflammatory response syndrome (SIRS) due to infection.
  • It involves massive activation of host defense mechanisms, potentially leading to multiple organ dysfunction syndrome.
  • The energetic and metabolic demands of SIRS can exceed the body's compensatory capacity, resulting in shock and high mortality rates (40-70% in septic shock).

Purpose:

  • To describe the pathogenesis, diagnosis, and therapy of sepsis.
  • To explain the pathogenetic role of intoxication, which can induce SIRS even without infection.
  • To provide guidance on antibiotic selection for sepsis management.

Summary:

  • Sepsis is a complex inflammatory response to infection, characterized by significant metabolic strain and potential organ failure.

Related Experiment Videos

  • Intoxication, independent of infection, can also trigger SIRS.
  • Antibiotic choice is critical; penicillins and carbapenems are favored over cephalosporins due to specific binding properties and reduced endotoxin release, minimizing Jarisch-Herxheimer reactions and TNF-alpha induction.

    • Impact:

    • Highlights the critical therapeutic challenge posed by sepsis and septic shock.
    • Emphasizes the importance of understanding the underlying mechanisms, including the role of toxins.
    • Offers practical recommendations for antibiotic therapy to mitigate adverse effects and improve treatment efficacy.