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Related Experiment Videos

Haloperidol overdose during pregnancy.

L M Hansen1, G Megerian, A E Donnenfeld

  • 1Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19107, USA.

Obstetrics and Gynecology
|January 5, 2002
PubMed
Summary
This summary is machine-generated.

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Pregnancy haloperidol overdose is rare but can cause maternal extrapyramidal reactions and temporary fetal akinesia. Prolonged fetal neuromuscular depression may occur following this severe medication event.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Psychiatry

Background:

  • Suicide attempts during pregnancy are infrequent, with over-the-counter and psychotropic medications being common agents.
  • While haloperidol overdose is documented in nonpregnant adults, its occurrence during pregnancy is not previously reported.
  • This case examines maternal and fetal responses to a suicide attempt involving haloperidol overdose during gestation.

Observation:

  • A pregnant patient at 34 weeks' gestation ingested 300 mg of haloperidol.
  • Maternal effects included unresponsiveness and an extrapyramidal reaction.
  • Fetal responses comprised temporary akinesia and a nonreactive nonstress test.

Findings:

  • The mother recovered within 48 hours following the haloperidol overdose.

Related Experiment Videos

  • The fetus exhibited prolonged neuromuscular depression, with a biophysical profile score of ten not achieved until 5 days post-presentation.
  • Haloperidol overdose during pregnancy can lead to significant maternal and fetal complications.

    • Implications:

    • This case highlights the potential risks of antipsychotic medication overdose in pregnant individuals.
    • It underscores the importance of monitoring fetal well-being closely after maternal exposure to toxic levels of haloperidol.
    • Further research is warranted to understand the long-term effects and management strategies for such events.