Search research articles

Search research articles

Related Experiment Videos

Uncertainties in the reference dose for methylmercury.

M L Dourson¹, A E Wullenweber, K A Poirier

¹Toxicology Excellence for Risk Assessment, Cincinnati, OH 45223, USA. dourson@tera.org

Neurotoxicology

|January 5, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Consideration of carcinogenicity and mode of action information by an independent expert panel to support derivation of no-significant-risk-level values for vinyl acetate monomer.

Regulatory toxicology and pharmacology : RTP·2026

Same author

The effect of various seleno-compounds on ehrlich ascites tumor cells.

Biological trace element research·2013

Same author

Genetic polymorphisms in assessing interindividual variability in delivered dose.

Regulatory toxicology and pharmacology : RTP·2002

Same author

Determination of an acute no-observed-adverse-effect level (NOAEL) for copper in water.

Regulatory toxicology and pharmacology : RTP·2001

Same author

Using human data to protect the public's health.

Regulatory toxicology and pharmacology : RTP·2001

Same author

Applications of mechanistic data in risk assessment: the past, present, and future.

Toxicological sciences : an official journal of the Society of Toxicology·2001

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

This study analyzes the methylmercury Reference Dose (RfD), questioning the chosen critical study and uncertainty factors (UFs). Further research is recommended to improve the RfD

Area of Science:

Environmental toxicology
Risk assessment
Methylmercury toxicity

Background:

Critically examines the National Academy of Sciences and National Research Council report on methylmercury.
Evaluates the US Environmental Protection Agency's Reference Dose (RfD) for methylmercury.

Purpose of the Study:

To scrutinize the selection of the critical study for the methylmercury RfD.
To analyze the assumptions and uncertainty factors (UFs) used in RfD derivation.
To compare UFs used by different agencies.

Main Methods:

Critical analysis of toxicological data and RfD methodology.
Examination of uncertainty factor selection and rationale.
Comparative review of UF approaches across organizations.

Related Experiment Videos

Main Results:

Identifies concerns regarding the critical study choice and UF assumptions in the current methylmercury RfD.
Highlights variability and rationale behind UF selection by different bodies.
Suggests specific research to reduce uncertainty in UF application.

Conclusions:

The current methylmercury RfD may lack precision due to chosen critical study and UF assumptions.
Further research can refine UF selection, potentially leading to a more accurate RfD.
Database completeness could enable a UF of unity, enhancing RfD precision.