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Related Experiment Videos

Bronchial hysteresis in excised lungs.

J M Hughes, H A Jones, A G Wilson

    The Journal of Physiology
    |August 1, 1975
    PubMed
    Summary

    Bronchial hysteresis, the airway

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    Area of Science:

    • Pulmonary physiology
    • Respiratory mechanics
    • Airway smooth muscle physiology

    Background:

    • Lung mechanics involve complex interactions between airways and parenchyma.
    • Bronchial hysteresis, the difference in airway diameter during inflation and deflation, is not fully understood.
    • The role of airway smooth muscle tone in intrinsic bronchial hysteresis requires further investigation.

    Purpose of the Study:

    • To investigate the intrinsic hysteresis of intrapulmonary bronchi.
    • To differentiate bronchial hysteresis from parenchymal hysteresis.
    • To determine the contribution of bronchial smooth muscle tone to hysteresis.

    Main Methods:

    • Excised dog lungs were filled with air, saline, Ringer, or EDTA solutions.
    • Intrapulmonary bronchi were visualized using tantalum dust and stereoscopic radiography.
    • Airway dimensions were measured during deflation and inflation at specific transpulmonary pressures.

    Main Results:

    • A significant deflation-inflation diameter difference (20%) was observed in air-filled lungs.
    • This difference reduced substantially with saline (9%) and EDTA solutions (2%).
    • EDTA's effect suggests a reduction in smooth muscle tone contributes to decreased hysteresis.

    Conclusions:

    • Intrapulmonary bronchi exhibit intrinsic hysteresis independent of surrounding lung tissue.
    • Bronchial smooth muscle tone is the primary determinant of this intrinsic hysteresis.
    • Understanding bronchial hysteresis is crucial for respiratory mechanics research.

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