Related Experiment Video
Updated: Aug 11, 2026

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
The trans-septal approach to the mitral valve
1Gleneagles Medical Centre, 1 Jalan Pangkor, 10050 Penang.
The trans-septal approach to mitral valve surgery is effective, showing good patient outcomes and a notable conversion rate from atrial fibrillation to sinus rhythm. This method offers a useful alternative for select patients needing mitral valve repair or replacement.
Area of Science:
- Cardiovascular Surgery
- Cardiac Surgery Techniques
- Minimally Invasive Cardiac Surgery
Background:
- The standard left atriotomy approach for mitral valve surgery is well-established.
- Alternative surgical approaches are continuously being evaluated to improve patient outcomes and reduce complications.
- The trans-septal approach offers a potentially less invasive route to the mitral valve.
Purpose of the Study:
- To evaluate the efficacy and outcomes of the trans-septal approach for mitral valve surgery.
- To compare the trans-septal approach with the conventional left atriotomy in terms of operative results and functional recovery.
- To assess the impact of the trans-septal approach on atrial fibrillation conversion.
Main Methods:
- A comparative study involving 40 patients undergoing mitral valve surgery via a trans-septal approach and 37 patients via a standard left atriotomy.
- Inclusion of various concomitant cardiac procedures such as tricuspid annuloplasty, aortic valve replacement, and coronary artery bypass grafting.
- Follow-up of patients for up to 18 months to assess functional status (NYHA classes) and rhythm conversion.
Main Results:
- Low operative mortality rate of 1.2% with no patients requiring pacemaker implantation.
- All patients in both groups achieved favorable functional status, classified as NYHA classes I and II post-surgery.
- A significant conversion rate from atrial fibrillation to sinus rhythm (one-third of patients) was observed in the trans-septal group, unlike the left atriotomy group (p < 0.02).
Conclusions:
- The trans-septal approach to mitral valve surgery is a viable and effective technique for selected patients.
- This approach demonstrates favorable short-term outcomes, including low mortality and excellent functional recovery.
- The trans-septal approach shows a promising benefit in converting atrial fibrillation to sinus rhythm, a significant advantage over the conventional method.
Related Concept Videos
Mitral Valve Prolapse I: Introduction
Mitral Valve Prolapse II: Assessment and Management
Mitral Regurgitation III: Medical Management
Mitral Stenosis I: Introduction
Mitral Stenosis II: Clinical features and Diagnostic Tests
Mitral Stenosis III: Medical Management

