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[Spatial registration of data on gene expression in situ]
E M Miasnikova1, A A Samsonova, M G Samsonova
1Dept. of Applied Math. and Statistics, University at Stony Brook, Stony Brook, NY 11794-3600, USA.
Molekuliarnaia Biologiia
|January 5, 2002
Abstract:
For registering data on the in situ expression of segmentation genes, a method of image registration was developed basing on the spline approximation. The reference points for the registration were the coordinates of extrema in one-dimensional patterns of gene expression. This registration method is characterized by a very high accuracy. A method of creating a generalized pattern of gene expression in single cells is proposed. Such patterns were constructed for nine segmentation genes belonging to the gap and pair-rule classes of genes.