[NO-synthase and cardiovascular gene therapy]

Molecular biology research of vascular remodeling paved the way to novel therapeutic approaches in experimental cardiology. Using gene transfer methods in various animal models, it has been shown that overexpression of nitric oxide synthase (NOS) can inhibit neointimal lesion proliferation. This review summarizes pivotal data regarding NO synthase gene manipulation in the cardiovascular system which enabled transition of this experimental approach from the bench to the clinical arena.