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Combining X-Ray Crystallography with Small Angle X-Ray Scattering to Model Unstructured Regions of Nsa1 from S. Cerevisiae
Published on: January 10, 2018
Internal derivatization of oligonucleotides with selenium for X-ray crystallography using MAD
Quan Du1, Nicolas Carrasco, Marianna Teplova
1Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York 11210, USA.
Journal of the American Chemical Society
|January 5, 2002
Abstract:
We have developed a route for the synthesis of 2'-selenium uridine analogues and oligonucleotides containing selenium labels, and have demonstrated for the first time a new strategy to covalently derivatize nucleotides with selenium for phase and structure determination in X-ray crystallography.

