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Selective ring opening cross metathesis of cyclooctadiene and trisubstituted cycloolefins
John P Morgan1, Christie Morrill, Robert H Grubbs
1The Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Organic Letters
|January 5, 2002
Abstract:
[reaction: see text] The selective ring opening cross metathesis of 1,5-cyclooctadiene and trisubstituted cycloolefins with acroyl species is described. The ring-opened products contain electronically differentiated olefins suitable for additional metathesis reactions. Trisubstituted cycloolefins open regioselectively, placing the acroyl cap on the less-substituted terminus.