Related Experiment Videos
Novel 1,4-benzodiazepines from acylnitroso-derived hetero-Diels-Alder cycloadducts
Matthew D Surman1, Mark J Mulvihill, Marvin J Miller
1Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Organic Letters
|January 5, 2002
Abstract:
[reaction: see text] N(4)-Hydroxy-1,4-benzodiazepines were synthesized in a single step from synthetically versatile acylnitroso-derived hetero-Diels-Alder cycloadducts. The efficiency of this transformation was found to be dependent on the NH pK(a) of the cycloadduct sulfonamide.