Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Novel therapies in vasculitis.

C Thomas-Golbanov1, S Sridharan

  • 1Department of Rheumatologic and Immunologic Diseases, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Expert Opinion on Investigational Drugs
|January 5, 2002
PubMed
Summary

Managing vasculitis involves balancing disease control and drug toxicity. Effective strategies include minimizing glucocorticoids with cytotoxic drugs, immunosuppressives, and targeted therapies for specific vasculitis types.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective and Sensitive Fluorescent Detection of Cyanide by 8-hydroxyquinoline-based Chemodosimeter: Spectral and TD-DFT Studies.

Journal of fluorescence·2026
Same author

Spectroscopic and TD-DFT Studies on Colourimetric Detection of Cyanide by a Triphenylphosphine-based Chemodosimeter Via ICT Modulation.

Journal of fluorescence·2026
Same author

Variations in out-of-pocket spending and factors influencing catastrophic health expenditure of households with patients suffering from chronic conditions in four districts in Sri Lanka.

BMC health services research·2024
Same author

A practical approach to implementing incremental haemodialysis.

Journal of nephrology·2024
Same author

The Dhaka Call to Action to accelerate the control of cardiovascular diseases in South-East Asia.

Nature medicine·2024
Same author

Definitive Stereotactic Body Radiation Therapy in Early-Stage Solitary Hepatocellular Carcinoma: An Australian Multi-Institutional Review of Outcomes.

Clinical oncology (Royal College of Radiologists (Great Britain))·2023

Area of Science:

  • Rheumatology
  • Immunology
  • Pharmacology

Background:

  • Vasculitides present diverse clinical and pathological challenges.
  • Balancing disease control with drug toxicity is a primary therapeutic concern.

Purpose of the Study:

  • To review current therapeutic strategies for various vasculitides.
  • To highlight the role of different drug classes and emerging treatments.

Main Methods:

  • Review of established and novel pharmacological agents.
  • Discussion of immunosuppressives, cytotoxic drugs, and targeted therapies.
  • Consideration of plasmapheresis, IVIG, and transplantation.

Main Results:

  • Glucocorticoids are central but can be optimized with other agents.
  • Cyclophosphamide is effective, with methotrexate for maintenance.
  • Targeted therapies exist for infections (e.g., hepatitis B/C-associated vasculitis).
  • Other agents include trimethoprim-sulfamethoxazole, thalidomide, and etanercept.
  • Monoclonal antibodies and transplantation are options for refractory cases.

Conclusions:

  • A multimodal approach is essential for managing vasculitis.
  • Minimizing glucocorticoid toxicity through alternative agents is key.
  • Personalized treatment strategies are crucial for optimal outcomes.

Related Experiment Videos