Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statins and inflammatory markers.

Christopher C Case1, Christie M Ballantyne

  • 1Baylor College of Medicine, 6565 Fannin, M.S. A-601, Houston, TX 77030, USA.

Current Atherosclerosis Reports
|January 5, 2002
PubMed
Summary

Statins reduce cardiovascular events by targeting inflammation, a key factor in atherosclerosis. They lower inflammatory markers, offering new therapeutic strategies for atherothrombotic disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

The lancet. Diabetes & endocrinology·2017
Same author

The association of lipoprotein(a) with incident heart failure hospitalization: Atherosclerosis Risk in Communities study.

Atherosclerosis·2017
Same author

Serum vitamin D and change in lipid levels over 5 y: The Atherosclerosis Risk in Communities study.

Nutrition (Burbank, Los Angeles County, Calif.)·2017
Same author

A simplified pathway to proprotein convertase subtilisin/kexin type 9 inhibitor prior authorization approval: A lipid clinic experience.

Journal of clinical lipidology·2017
Same author

The Upregulation of Integrin α<sub>D</sub>β<sub>2</sub> (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis.

Journal of immunology (Baltimore, Md. : 1950)·2017
Same author

Dyslipidaemia: PCSK9 inhibitors and foamy monocytes in familial hypercholesterolaemia.

Nature reviews. Cardiology·2017

Area of Science:

  • Cardiovascular Science
  • Inflammation Biology
  • Pharmacology

Background:

  • Inflammation plays a critical role in atherosclerosis development and cardiovascular events.
  • Inflammatory markers like C-reactive protein predict cardiovascular risk.
  • Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) reduce cholesterol synthesis and cardiovascular mortality.

Purpose of the Study:

  • To review the biology, epidemiology, and clinical trial data on statins' effects on inflammatory markers in atherosclerosis.

Main Methods:

  • Review of existing literature on inflammation in atherosclerosis.
  • Analysis of clinical trial data regarding statin use and inflammatory markers.

Main Results:

  • Statins modulate inflammatory mechanisms in atherosclerosis.
  • Clinical trials show statins reduce levels of key inflammatory markers.

Conclusions:

  • Statins demonstrate anti-inflammatory effects beyond cholesterol reduction.
  • Targeting inflammatory markers with statins is a promising strategy for atherothrombotic disease management.

Related Experiment Videos