Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dolasetron for preventing postanesthetic shivering.

Swen N Piper1, Kerstin D Röhm, Wolfgang H Maleck

  • 1Department of Anesthesiology and Critical Care Medicine, Klinikum Ludwigshafen, Ludwigshafen, Germany.

Anesthesia and Analgesia
|January 5, 2002
PubMed
Summary

Clonidine effectively prevents postanesthetic shivering, unlike dolasetron. This study found clonidine significantly reduced shivering incidence and severity after surgery, while dolasetron showed no significant benefit compared to placebo.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Hydroxyethylstarch as a Risk Factor for Acute Renal Failure : Is a Change of Clinical Practice Indicated?

Drug safety·2026
Same author

Sudden hemodynamic collapse and biventricular dysfunction: What's your diagnosis?

Intensive care medicine·2026
Same author

Saline versus balanced hydroxyethyl starch: does it matter? RETRACTION.

Current opinion in anaesthesiology·2025
Same author

Developing a Data Trust Model (Not Only) for Sleep Research: Conceptual Study and Quantitative Survey.

JMIR human factors·2025
Same author

Retraction Note to: Hydroxyethylstärke (HES).

Wiener klinische Wochenschrift·2025
Same author

Ethical, Legal, and Practical Concerns Surrounding the Implemention of New Forms of Consent for Health Data Research: Qualitative Interview Study.

Journal of medical Internet research·2024

Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Postanesthetic shivering is a common complication following general anesthesia.
  • It is characterized by irregular muscular fasciculations lasting longer than 15 seconds.

Purpose of the Study:

  • To evaluate the efficacy of dolasetron compared to clonidine and placebo for preventing postanesthetic shivering.
  • To determine if dolasetron is a viable alternative to established treatments like clonidine.

Main Methods:

  • A double-blind, randomized study included 90 patients undergoing elective abdominal or urologic surgery.
  • Patients were assigned to receive either dolasetron (12.5 mg), clonidine (3 microg/kg), or placebo after anesthesia induction.
  • Shivering severity was assessed using a five-point scale.

Related Experiment Videos

Main Results:

  • Clonidine demonstrated significant efficacy, with 86.6% of patients in this group experiencing no shivering.
  • Dolasetron (63.3%) and placebo (66.6%) groups showed similar, lower rates of symptom-free patients.
  • Clonidine significantly reduced both the incidence and severity of postanesthetic shivering.

Conclusions:

  • Clonidine is effective in preventing postanesthetic shivering when administered before surgery.
  • Dolasetron, at the tested dose of 12.5 mg, was not effective in preventing postanesthetic shivering.
  • Clonidine remains an effective option for managing postanesthetic shivering, while dolasetron does not appear to be at this dosage.