The quantitative aspects of drug-receptor interactions

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Targeting melanoma with NT157 by blocking Stat3 and IGF1R signaling.

Oncogene·2015

Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents.

Oncogene·2010

Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor.

Oncogene·2006

Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.

Biochemical pharmacology·2006

Stochastic algorithm for kinase homology model construction.

Current medicinal chemistry·2004

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Journal of molecular biology·2026

In vivo single-molecule tracking of CHD family chromatin remodeler Hrp3 defines the chromatin context-dependent binding dynamics in S. pombe.

Journal of molecular biology·2026

Coiled-Coil Domain Kinking Controls Laminin-332 Cleavage by Elastase.

Journal of molecular biology·2026

The GCN2-ATF4 signaling axis orchestrates the hepatic transcriptional stress response to short-term sulfur amino acid deprivation.

Journal of molecular biology·2026

URG7-Driven Homeostatic Adaptation Protects SH-SY5Y Cells from 6-OHDA Neurotoxicity.

Journal of molecular biology·2026

New structures of human formylglycine-generating enzyme reveal features important for catalysis, disease and structure-based drug design.

Journal of molecular biology·2026

Astragaloside IV Protects against PM2.5-Induced Spermatocyte Injury via the cGAS-STING/Nrf2/HMOX1 Axis.

Reproductive toxicology (Elmsford, N.Y.)·2026

Alleviation of senkyunolide A on hyperuricemia and hyperuricemia-induced renal damage in rats.

Biochemical and biophysical research communications·2026

Pharmacological investigation of a selected triazole derivative against acetic acid-induced ulcerative colitis in mouse model.

Biochemical and biophysical research communications·2026

Integrated experimental and computational investigation of sophoridine derivatives reveals antitumor potential and Topo I-associated mechanisms.

European journal of medicinal chemistry·2026

Discovery of Aspxanthones A-I with SIRT1 agonist activity from Aspergillus sp. TJ507.

Bioorganic chemistry·2026

Benzo[h]quinoline-based heterocyclic derivatives as Culex pipiens larvicidal candidates: synthesis, bioactivity, biochemical response, and in silico mechanistic insights.

Bioorganic chemistry·2026

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The quantitative aspects of drug-receptor interactions

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Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.

Targeting melanoma with NT157 by blocking Stat3 and IGF1R signaling.

Status of p53 in human cancer cells does not predict efficacy of CHK1 kinase inhibitors combined with chemotherapeutic agents.

Cisplatin induces PKB/Akt activation and p38(MAPK) phosphorylation of the EGF receptor.

Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.

Stochastic algorithm for kinase homology model construction.

Insights into Genome Ejection by a Therapeutic phiKMV-like Bacteriophage.

In vivo single-molecule tracking of CHD family chromatin remodeler Hrp3 defines the chromatin context-dependent binding dynamics in S. pombe.

Coiled-Coil Domain Kinking Controls Laminin-332 Cleavage by Elastase.

The GCN2-ATF4 signaling axis orchestrates the hepatic transcriptional stress response to short-term sulfur amino acid deprivation.

URG7-Driven Homeostatic Adaptation Protects SH-SY5Y Cells from 6-OHDA Neurotoxicity.

New structures of human formylglycine-generating enzyme reveal features important for catalysis, disease and structure-based drug design.

Astragaloside IV Protects against PM2.5-Induced Spermatocyte Injury via the cGAS-STING/Nrf2/HMOX1 Axis.

Alleviation of senkyunolide A on hyperuricemia and hyperuricemia-induced renal damage in rats.

Pharmacological investigation of a selected triazole derivative against acetic acid-induced ulcerative colitis in mouse model.

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The quantitative aspects of drug-receptor interactions

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