Related Experiment Video

Updated: Oct 3, 2026

Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels
08:37

Liver Cold Storage and Transplantation in the Cold-Adaptive Daurian Ground Squirrels

Published on: July 3, 2025

Progression of hepatic damage during cold storage after procurement in a liver and kidney donor with HELLP syndrome

K J Woodside1, A S Knisely, A W Strauss

  • 1Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0534, USA.

Transplantation
|January 5, 2002
PubMed

Insights

HELLP syndrome can cause rapid liver damage, even after organ procurement. Careful evaluation of liver grafts from these donors is crucial to prevent transplant complications.

Area of Science:

  • Hepatology
  • Transplant Surgery
  • Obstetrics

Background:

  • HELLP syndrome, a condition linked to preeclampsia, involves hemolysis, elevated liver enzymes, and low platelets.
  • It is associated with fetal metabolic defects in fatty acid metabolism, leading to maternal liver toxicity.

Observation:

  • A case of a liver and kidney donor with HELLP syndrome was analyzed.
  • Liver biopsy before procurement showed minimal necrosis, but after cold storage, necrosis exceeded 30%.

Findings:

  • The donor liver exhibited significant progression of hepatic damage during cold storage.
  • The liver was not transplanted, while the kidneys were successfully engrafted.

Implications:

  • Organs from HELLP syndrome donors require meticulous assessment for cold ischemic injury.
  • This highlights the importance of donor selection and organ viability assessment in transplantation.
Abstract

More Related Videos

Ex Situ Normothermic Machine Perfusion of Donor Livers12:13

Ex Situ Normothermic Machine Perfusion of Donor Livers

Published on: May 26, 2015

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...