Are we asking too much of our trials?

Left Atrial Structure and Function, Clinical Outcomes, and Efficacy of Vutrisiran in Transthyretin Amyloidosis With Cardiomyopathy: A Secondary Analysis of the HELIOS-B Randomized Clinical Trial.

JAMA cardiology·2026

Prognostic impact of systolic blood pressure trajectory among patients hospitalised in an acute heart failure setting: insights from a real-world multinational cohort.

Swiss medical weekly·2026

Heart rate and atrial fibrillation/flutter in HFmrEF/HFpEF: a participant-level analysis across five randomized clinical trials.

European journal of heart failure·2026

Alterations in Cardiac Structure and Function Associated With Sub-Severe Aortic Stenosis Progression: The ARIC Study.

Journal of the American Heart Association·2026

Prevalence, Clinical Correlates, and Prognostic Impact of Tricuspid Regurgitation in Older Adults: The ARIC Study.

Journal of the American Heart Association·2025

Sleep Apnea and Cardiac Structure and Function in Patients With Heart Failure with Preserved Ejection Fraction: Insights From the PARAGON-HF Trial.

Journal of cardiac failure·2025

Cleaner Air for Lower Cardiometabolic Risk: protocol for a double-blind, randomized, sham-controlled trial of HEPA filtration in adults with prediabetes.

American heart journal·2026

Cardiac Allograft Vasculopathy and Secondary Outcomes at 1-year in Heart Transplantation from Circulatory Death Donors.

American heart journal·2026

Dental Procedures and Associated Risk of Infective Endocarditis.

American heart journal·2026

Recurrent myocardial infarction identified by centralized troponin review: Insights from the MINT trial.

American heart journal·2026

Pregnancy Outcomes in Women with a History of Myocarditis.

American heart journal·2026

HPS-4/TIMI 65/ORION-4: A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease: Trial design, recruitment, and baseline characteristics.

American heart journal·2026

A Staged Hybrid Technique for Large Benign Colorectal Polyps with Severe Fibrosis: A Retrospective Cohort Study.

Endoscopy international open·2026

A Cardiac Time Bomb: Stroke as the Initial Presentation of a Large Atrial Myxoma.

Cureus·2026

New progress and clinical research translation of immune checkpoint inhibitors in systemic therapy of gallbladder cancer.

Frontiers in immunology·2026

Malignant Phyllodes Tumor of the Breast With Multiple Heterologous Sarcomatous Differentiations and Focal Rhabdoid-Like Features: A Case Report.

Cureus·2026

The Great Imitator Behind a Rare Mask: Secondary Syphilis Diagnosed During an Atypical Flare of Tumoral Calcinosis.

Cureus·2026

Cancer pain.

Nature reviews. Disease primers·2026

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Are we asking too much of our trials?

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Left Atrial Structure and Function, Clinical Outcomes, and Efficacy of Vutrisiran in Transthyretin Amyloidosis With Cardiomyopathy: A Secondary Analysis of the HELIOS-B Randomized Clinical Trial.

Prognostic impact of systolic blood pressure trajectory among patients hospitalised in an acute heart failure setting: insights from a real-world multinational cohort.

Heart rate and atrial fibrillation/flutter in HFmrEF/HFpEF: a participant-level analysis across five randomized clinical trials.

Alterations in Cardiac Structure and Function Associated With Sub-Severe Aortic Stenosis Progression: The ARIC Study.

Prevalence, Clinical Correlates, and Prognostic Impact of Tricuspid Regurgitation in Older Adults: The ARIC Study.

Sleep Apnea and Cardiac Structure and Function in Patients With Heart Failure with Preserved Ejection Fraction: Insights From the PARAGON-HF Trial.

Cleaner Air for Lower Cardiometabolic Risk: protocol for a double-blind, randomized, sham-controlled trial of HEPA filtration in adults with prediabetes.

Cardiac Allograft Vasculopathy and Secondary Outcomes at 1-year in Heart Transplantation from Circulatory Death Donors.

Dental Procedures and Associated Risk of Infective Endocarditis.

Recurrent myocardial infarction identified by centralized troponin review: Insights from the MINT trial.

Pregnancy Outcomes in Women with a History of Myocarditis.

HPS-4/TIMI 65/ORION-4: A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease: Trial design, recruitment, and baseline characteristics.

A Staged Hybrid Technique for Large Benign Colorectal Polyps with Severe Fibrosis: A Retrospective Cohort Study.

A Cardiac Time Bomb: Stroke as the Initial Presentation of a Large Atrial Myxoma.

New progress and clinical research translation of immune checkpoint inhibitors in systemic therapy of gallbladder cancer.

Malignant Phyllodes Tumor of the Breast With Multiple Heterologous Sarcomatous Differentiations and Focal Rhabdoid-Like Features: A Case Report.

The Great Imitator Behind a Rare Mask: Secondary Syphilis Diagnosed During an Atypical Flare of Tumoral Calcinosis.

Cancer pain.

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Are we asking too much of our trials?

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