Search research articles

Search research articles

Related Experiment Videos

Hepatitis C virus genotyping: clinical implications and methods.

¹Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. fnolte@emopry.edu

Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology

|January 5, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluation of Abbott ID NOW COVID-19 POC test performance characteristics and integration in the regional health network workflows to improve health care delivery.

Clinical biochemistry·2021

Same author

Detection and typing of hepatitis C virus.

Methods in molecular medicine·2011

Same author

Pseudo-outbreak of Legionella pneumophila serogroup 8 infection associated with a contaminated ice machine in a bronchoscopy suite.

Infection control and hospital epidemiology·2009

Same author

Posaconazole treatment for Apophysomyces elegans rhino-orbital zygomycosis following trauma for a male with well-controlled diabetes.

Journal of clinical microbiology·2007

Same author

Acanthamoeba castellani encephalitis following partially mismatched related donor peripheral stem cell transplantation.

Transplant infectious disease : an official journal of the Transplantation Society·2004

Same author

Prospective multicenter clinical evaluation of AMPLICOR and COBAS AMPLICOR hepatitis C virus tests.

Journal of clinical microbiology·2001

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Hepatitis C virus (HCV) causes chronic liver disease globally. Identifying HCV genotype through nucleotide sequencing is crucial for predicting treatment response and duration.

Area of Science:

Hepatology
Virology
Genetics

Background:

Hepatitis C virus (HCV) chronically infects over 1% of the global population, leading to end-stage liver disease.
HCV exhibits significant genomic diversity with six major genotypes and numerous subtypes, varying by geographic distribution.
Viral genomic plasticity and quasispecies evolution enable persistent HCV infections.

Purpose of the Study:

To highlight the importance of Hepatitis C virus (HCV) genotype in predicting antiviral therapy outcomes.
To emphasize the role of genomic diversity in HCV persistence and treatment response.
To underscore the significance of accurate HCV genotyping methods.

Main Methods:

Review of existing literature on HCV genotyping methods.

Related Experiment Videos

Analysis of the impact of HCV genotype on antiviral therapy.

Nucleotide sequencing of phylogenetically informative regions as the gold standard for HCV genotyping.

Main Results:

HCV genotype is a critical factor in predicting sustained virologic response to therapy.
Genotype influences the optimal duration of antiviral treatment for Hepatitis C.
Genomic diversity and quasispecies evolution contribute to treatment challenges.

Conclusions:

Accurate determination of Hepatitis C virus (HCV) genotype is essential for effective patient management.
Nucleotide sequencing provides the most reliable method for HCV genotyping.
Understanding HCV genomic diversity is key to improving treatment strategies and outcomes.