Related Experiment Video
Updated: Oct 3, 2026

Serum and Plasma Copy Number Detection Using Real-time PCR
Published on: December 15, 2017
[The polymorphism of (CAG)n repeats within androgen receptor gene among Chinese male population]
1Department of Pathophysiology, the Second Military Medical University, Shanghai, 200433 P. R. China. Lujian@smmu.edu.cn
Objective:
To investigate the polymorphism of (CAG)n repeats within androgen receptor (AR) gene among normal Chinese male population.
Methods:
dsDNA cycle sequencing and[alpha-(32)PdCTP] incorporated asymmol/Letric PCR-denaturing polyacrylamide gel electrophoresis(PAGE) were used to determine the number of (CAG)n repeats in normal men (n=107).
Results:
The number of polymorphic (CAG)n repeats ranges from 11 to 29; the most frequent repeat is 22(20/107); the less frequent repeats are 23(15/107), 24(11/107), 21(11/107) and 20(8/107).
Conclusion:
The AR gene (CAG)n exhibits polymorphism among normal male population and the present work could serve as a basis for further exploration of its pathological and genetic significance.
Related Concept Videos
Single Nucleotide Polymorphisms-SNPs
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Histone Variants at the Centromere

