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[The experimental study of immunization with purified surface protein antigen I/II from streptococcus mutans in
Abstract
Objective:
To study the immunogenicity and immunoreactivity of purified surface protein antigen I/II from streptococcus mutans.
Methods:
Purified antigen I/II was used to immune BALB/c mice by subcutaneous injection route, and S. mutans whole cells were used as comparison.
Results:
ELISA showed immunization with antigen I/II highly induced both specific serum IgG antibody and specific salivary IgA antibody against antigen I/II (P < 0.01), but immunization with whole cells only induced specific serum IgG antibody (P < 0.05).
Conclusion:
The study suggest purified antigen I/II is an effective candidate vaccine.