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[Modulating effects of thymopentin on the immune system of severely burned patients]
1Burn Center, First Affiliated Hospital of Jiangxi Medical College, Nan Chang 330006, Jiang Xi Province, P. R. China.
Objective:
To explore the modulating effects of thymopentin (TP-5) on the immune system of severely burned patients.
Methods:
Sixty patients with severe burn were enrolled in this study and were randomly divided into treatment (T, n = 30) and control (C, n = 30) groups. The T lymphocytes and NK cells in peripheral blood in two groups were determined on the 2, 5, 8, 15 and 22 postburn days (PBDs). The patients in T group were treated with TP-5 in a dose of 1 mg/d for 20 days beginning on 2 PBD.
Results:
There was no difference of T lymphocytes and NK cells between the two groups on 2 PBD, and there was no difference of total number in T lymphocytes between the two groups on 5, 8, 15 and 22 PBDs. But the NK cell number and CD4/CD8 ratio in C group were much lower than those in T group.
Conclusion:
The function of T lymphocytes and NK cells in severely burned patients could be obviously improved by TP-5, which played immune modulating roles.